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Dopamine and male orgasm

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  • 25.06.2019
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Orgasm and ejaculation are two separate physiological processes that are sometimes difficult to distinguish. Orgasm is an intense transient peak sensation of intense pleasure creating an altered state of consciousness associated with reported physical changes. Antegrade ejaculation is a complex physiological process that is composed of two phases emission and expulsion , and is influenced by intricate neurological and hormonal pathways. Despite the many published research projects dealing with the physiology of orgasm and ejaculation, much about this topic is still unknown. Ejaculatory dysfunction is a common disorder, and currently has no definitive cure.
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Postcoital Neurochemistry: The Blues and the Highs

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What Happens to Your Brain When You Have Sex | TheThirty

It is well known that anti-depressants can have sexual side effects. They can lead to problems with desire, arousal, ejaculation , and orgasm. These sexual problems are most associated with the use of two drug classes—selective serotonin reuptake inhibitors SSRIs and serotonin-norepinephrine reuptake inhibitors SNRI. Very early on in the development of SSRIs, it was discovered that these medications can cause difficulties with ejaculation. In fact, these medications are actually sometimes prescribed for men who have problems with premature ejaculation.
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Normal male sexual function: emphasis on orgasm and ejaculation

Steroid hormones regulate sexual behavior primarily by slow, genomically mediated effects. Dopamine has facilitative effects on sexual motivation, copulatory proficiency, and genital reflexes. Dopamine in the nigrostriatal tract influences motor activity; in the mesolimbic tract it activates numerous motivated behaviors, including copulation; in the medial preoptic area MPOA it controls genital reflexes, copulatory patterns, and specifically sexual motivation. Testosterone increases nitric oxide synthase in the MPOA; nitric oxide increases basal and female-stimulated dopamine release, which in turn facilitates copulation and genital reflexes. Serotonin 5-HT is primarily inhibitory, although stimulation of 5-HT 2C receptors increases erections and inhibits ejaculation, whereas stimulation of 5-HT 1A receptors has the opposite effects: facilitation of ejaculation and, in some circumstances, inhibition of erection.
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You don't need anyone to tell you that orgasms are magical. It's possible, though, that you don't know just how vital they are to our lives outside the bedroom. Women especially have a complex network of pelvic nerves that branch from the clitoris, vagina, and cervix to the spinal cord, and then up to the brain.
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