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Leukocytes in sperm

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  • 06.01.2019
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Treatment of Leukocytospermia in Male Infertility: A Systematic Review

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White Blood Cells in Semen - When Are They a Problem?

This study set out to establish a new method, using flow cytometry, to evaluate leukocytes in semen. Ejaculates of 59 males, asymptomatic for genitourinary infections, were examined. Routine semen analyses were carried out as well as peroxidase and polymorphonuclear granulocyte—elastase detection. Leukocytes were detected combining flow cytometry and monoclonal antibodies anti-CD45, anti-CD This technique reliably assessed the total number of leukocytes and differentiated subpopulations even at low concentrations. The peroxidase test and elastase determination showed good specificity, but only moderate sensitivity versus flow cytometry combined with monoclonal antibodies.
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Pyospermia

To evaluate the association between leukocytes polymorphonuclear granulocytes -PMNL and semen parameters at different leukocyte concentrations. This was a retrospective clinical study at a university hospital andrology clinic. Sperm deformities and motility grades c and d increased progressively in all categories. The findings suggest that the association between leukocytes PMNL and semen quality might be concentration dependent.
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Leukocytospermia is a well-known indicator of infection or inflammation in the male sex glands and the urogenital tract. Although great deal of effort has been expended to elucidate definite management strategies in infertile men with leukocytospermia, the gold standard of treatment remains unclear. Until recently, broad spectrum antibiotics and antioxidants have been used in the treatment of leukocytospermia for male infertility to eliminate infection and reduce reactive oxygen free radicals produced inside cellular mitochondria as a result of inflammation.
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